Instead of reviewing the insert and the info at the official website of Adipex, the places where there is still some room for marketing, we’ll consider a comprehensive research conducted in South Korea in mid 00’s. Our choice is not random – the state of affairs around obesity in South Korea is quite similar to the one in the US, and the carried out study boasts comprehensive data and an impressive scope.
Phentermine, the active substance of Adipex, is referred to the group of sympathetic amines, providing an impact on norepinephrine secretion at nerve terminal. This way or the other, there’s no comprehensive data on the entire process of functioning of phentermine in the body. A number of researches on this matter say that the active substance provides a suppressive action on appetite at hypothalamus through acceleration of norepinephrine, dopamine and serotonin release in central nervous system.
The research has confirmed the capabilities of the drug: 80% of participants have managed to lose 5% of weight, and 50% of the group achieved a 10% and more weight loss result. In addition, the drug has contributed to a reduction in bad cholesterol in 88% of cases.
It is confirmed that the drug may provoke tachycardia and contribute to blood pressure surges, which is explained by its sympathomimetic action. Thus, almost 21% of participants complained about palpitation, and the frequency of the problem exceeded the identical number in placebo group by several times.
Importantly, there was no cases of increased blood pressure registered during post-treatment among Adipex participants, and there was no significant difference between phentermine and placebo patients group. Moreover, neither the increased blood pressure problems were registered during 4 week treatment with Adipex; the difference between the placebo group was negligible. As a result, the researchers arrived at a conclusion that the reception of phentermine is not inducing a noteworthy cardiovascular impact, at least in those cases with the absence of high cardiovascular risks in clinical picture.
The research didn’t reveal the high frequency of side effects, and significant adverse reactions were reported just a few times throughout the 12 + 2 weeks of treatment. Dry mouth and insomnia became the most frequent side effects the patients have collided with, although the time adjustments of the drug reception (reception during morning hours) have proved to have a positive impact, reducing the frequency of insomnia cases; while drinking plenty of water reduced the number of dry mouth episodes.