To answer the question in one sentence – the silver bullet doesn’t actually exist. The market offers a variety of solutions the effectiveness of which depends on individual characteristics and reaction of the body. Importantly, a selection of weight loss pills should not be carried out basing on the maximum fat burning efficiency, as pharmaceutical preparations in particular should be considered basing on indications for use, contraindications and adverse reactions risks.
Weight loss pills, often referred to as obesity or diet pills, are used in clinical practice in obesity treatment and weight loss acceleration. As a rule, in the absence of serious contraindications, these drugs are appointed along with the lifestyle changes, including dietary restrictions, adding regular physical exercising, giving up bad habits and etc. Therefore, consulting with a professional prior to initiation a course of weight loss pills has a paramount importance.
Considering performance indicators
Basically, you can choose from over the counter drugs and prescription medications (with certain reservations). Thus, for example, you may want to give a try to Xenical, available by prescription only, or give Alli a try. Both drugs are based on the same active substance, orlistat; however, Alli comes in a lower dose.
You may also want to consider dietary supplements and herbal remedies – these solutions are virtually deprived of side effects and contraindications; nevertheless, the efficiency of their use remains to be a doubtful aspect due to the lack of comprehensive clinical data. However, the exceptions are also there: in 2009 FDA has released a statement that drugs containing Cambodia Garcinia may have a significant negative impact on your liver. Selfsame, green cocktails and detox mixtures may provoke or aggravate gastrointestinal tract diseases (gastroduodenitis and even ulcer).
Furthermore, herbal preparations are not subjected to FDA approval in weight loss category, while the drugs produced abroad may not undergo composition control, meaning that you have no other option but to trust the fact the composition of the drug is identical to the one described in the inlet. Herbal remedies contribute up to roughly 4 – 9% of weight reduction, and the results are achieved within the ongoing treatment during 9 – 12 months.
Talking about pharmaceutical options, the choice is extensive enough – according to drugs.com, the list of the most prescribed drugs includes 12 preparations. However, prescription meds are typically cannot be referred to as silver bullet solutions – as a rule, weight loss pills are prescribed in the presence of serious risks to health posed by obesity, high levels of ‘bad’ cholesterol, diabetes and etc. Despite the widespread misconceptions, weight loss pills should not be considered as an alternative to regular exercising or healthy diet. The majority of the currently available meds enable you to lose 5 – 10% of weight in conjunction with lifestyle changes. However, let’s consider the facts (the data presented further is accumulated from various clinical trials and surveys reports).
In Xenical, one of the best-selling weight loss drugs, after 12 months of treatment, a decrease in body mass equaled 10.3%, the study involved 360mg of preparation consumed 3 times a day. The results are even more comprehensive in case the patient follow healthy diet and exercising recommendations. As for the clinical efficiency of Alli, the drug based on the identical active substance, but comes in a lower dosage, it was confirmed that the drug is capable of reducing weight from 6.5% to 11.5% in people with body mass index exceeding 30kg/m2.
Phentermine, the active substance of many popular weight loss drugs that has been added to the FDA registry in 1954, is confirmed to reduce weight by 5% in 60% of survey participants. However, these results are achieved within shorter periods of time (as a rule – 3-4 weeks) and the long-term treatment (12 weeks) is even contraindicated.
Contrave, the preparation recently appeared in the market after FDA approval in 2014, was tested in a 16-week study, has confirmed its weight loss capabilities – the preparation has contributed to 7 – 10% weight loss. However, the risk of seizure, the drug’s adverse reaction that was frequently observed in bupropion, its active ingredient, is still there.
If you are considering pharmaceutical or herbal weight loss treatment, ask your doctor to select an optimal preparation for you. Avoid using such preparations as Meridia – the drug was on the local market for a few years until its license was revoked by FDA in 2012 due to the significant risks to health it poses (however, it is still available in online drugstores).